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Article

Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages.

The Biochemical journal - 15 Feb 2017

Darling Nicola J, Toth Rachel, Arthur J Simon C, Clark Kristopher

Abstract excerpt

The salt-inducible kinases (SIKs) control a novel molecular switch regulating macrophage polarization. Pharmacological inhibition of the SIKs induces a macrophage phenotype characterized by the secretion of high levels of anti-inflammatory cytokines, including interleukin (IL)-10, and the secretion of very low levels of pro-inflammatory cytokines, such as tumour necrosis factor α. The SIKs, therefore, represent...

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Identifiers

PMID: 27920213
DOI: 10.1042/BCJ20160646
PMCID: PMC5290485

Genes

SIK2
SIK3
SIK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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