Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites.

Journal of leukocyte biology - 1 Sept 2008

Thomas Molly S, Mitchell Jason S, DeNucci Christopher C, Martin Amanda L, Shimizu Yoji

Abstract excerpt

The role of PI-3K in leukocyte function has been studied extensively. However, the specific role of the p110gamma isoform of PI- 3K in CD4 T lymphocyte function has yet to be defined explicitly. In this study, we report that although p110gamma does not regulate antigen-dependent CD4 T cell activation and proliferation, it plays a crucial role in regulating CD4 effector T cell migration. Naïve p110gamma(-/-) CD4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Chemokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Proto-Oncogene Proteins c-akt

Share to Receptors, Antigen, T-Cell

Share to Receptors, Chemokine

Source

Open in PubMed Open full text

Identifiers

PMID: 18523230
DOI: 10.1189/jlb.0807561
PMCID: PMC2516906

Genes

CCR4
CCL22
CCR7
CXCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites.PMID 18523230Read ↗

Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase.Semantic proximity Read ↗

The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic DiseasesSemantic proximity Read ↗

Role of PI3Kδ and PI3Kγ in inflammatory arthritis and tissue localization of neutrophilsSemantic proximity Read ↗

Role of class IA phosphoinositide 3-kinase in B lymphocyte development and functions.Semantic proximity Read ↗

CD3γ-independent pathways in TCR-mediated signaling in mature T and iNKT lymphocytes.Semantic proximity Read ↗

The role of PI3Kγ in the immune system: new insights and translational implicationsSemantic proximity Read ↗

Control of T lymphocyte fate decisions by PI3K signalingSemantic proximity Read ↗

Distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration.Semantic proximity Read ↗

Protein Kinase Cδ Promotes Transitional B Cell-Negative Selection and Limits Proximal B Cell Receptor Signaling To Enforce ToleranceSemantic proximity Read ↗

Both T and B cells contribute to dysregulated activation and differentiation of CD4 <sup>+</sup> T cells in Activated PI3K delta syndrome 1Semantic proximity Read ↗

KLRG1 binds cadherins and preferentially associates with SHIP-1.Semantic proximity Read ↗

The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.