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Article

CCM1 regulates vascular-lumen organization by inducing endothelial polarity.

Journal of cell science - 1 Apr 2010

Lampugnani Maria Grazia, Orsenigo Fabrizio, Rudini Noemi, Maddaluno Luigi, Boulday Gwénola, Chapon Francoise, Dejana Elisabetta

Abstract excerpt

Little is known about the molecular mechanisms that regulate the organization of vascular lumen. In this paper we show that lumen formation correlates with endothelial polarization. Adherens junctions (AJs) and VE-cadherin (VEC, encoded by CDH5) are required for endothelial apicobasal polarity in vitro and during embryonic development. Silencing of CDH5 gene expression leads to abrogation of endothelial polarity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemangioma, Cavernous, Central Nervous System

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Source

Identifiers

PMID: 20332120
DOI: 10.1242/jcs.059329

Genes

CDH5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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