Article
ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish.
Human molecular genetics - 15 Aug 2008
Hogan Benjamin M, Bussmann Jeroen, Wolburg Hartwig, Schulte-Merker Stefan
Abstract excerpt
Cerebral cavernous malformations (CCMs) are a prevalent class of vascular anomalies characterized by thin-walled clusters of malformed blood vessels in the brain. Heritable forms are caused by mutations in CCM1, CCM2 and CCM3, but despite the importance of these factors in vascular biology, an understanding of their molecular and cellular functions remains elusive. Here we describe the characterization of a...
Topics
- Animals
- Blood Vessels
- Endothelium
- Gene Expression Regulation, Developmental
- Humans
- Microtubule-Associated Proteins
- Models, Animal
- Morphogenesis
- Muscle Proteins
- Mutation
- Phenotype