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Article

Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice

5 Jun 2020

Abstract excerpt

Cerebral cavernous malformations (CCMs) are vascular lesions predominantly developing in the central nervous system (CNS), with no effective treatments other than surgery. Loss-of-function mutation in CCM1/krev interaction trapped 1 (KRIT1), CCM2, or CCM3/programmed cell death 10 (PDCD10) causes lesions that are characterized by abnormal vascular integrity. Vascular endothelial cadherin (VE-cadherin), a major...

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PMID: 32502201
DOI: 10.1371/journal.pbio.3000734

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