Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Genetic Features of Cerebral Cavernous Malformations (CCM) Patients: An Overall View from Genes to Endothelial Cells.

Cells - 22 Mar 2021

Riolo Giulia, Ricci Claudia, Battistini Stefania

Abstract excerpt

Cerebral cavernous malformations (CCMs) are vascular lesions that affect predominantly microvasculature in the brain and spinal cord. CCM can occur either in sporadic or familial form, characterized by autosomal dominant inheritance and development of multiple lesions throughout the patient's life. Three genes associated with CCM are known: CCM1/KRIT1 (krev interaction trapped 1), CCM2/MGC4607 (encoding a protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Carrier Proteins
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Mutation

Share to Phenotype

Share to Proto-Oncogene Proteins

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 33810005
DOI: 10.3390/cells10030704
PMCID: PMC8005105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Genetic Features of Cerebral Cavernous Malformations (CCM) Patients: An Overall View from Genes to Endothelial Cells.PMID 33810005Read ↗

From Genes and Mechanisms to Molecular-Targeted Therapies: The Long Climb to the Cure of Cerebral Cavernous Malformation (CCM) Disease.Semantic proximity Read ↗

Cerebral Cavernous Malformations: Review of the Genetic and Protein–Protein Interactions Resulting in Disease PathogenesisSemantic proximity Read ↗

Cerebral Cavernous Malformation Proteins in Barrier Maintenance and RegulationSemantic proximity Read ↗

Recent insights into cerebral cavernous malformations: the molecular genetics of CCM.Semantic proximity Read ↗

Cerebral cavernous malformations as a disease of vascular permeability: from bench to bedside with caution.Semantic proximity Read ↗

Cerebral Cavernous Malformation Pathogenesis: Investigating Lesion Formation and Progression with Animal Models.Semantic proximity Read ↗

Cerebral cavernous malformation: new molecular and clinical insightsSemantic proximity Read ↗

Cerebral cavernous malformations - An overview on genetics, clinical aspects and therapeutic strategies.Semantic proximity Read ↗

Cerebral cavernous malformations: from molecular pathogenesis to genetic counselling and clinical management.Semantic proximity Read ↗

Genetics of cerebral cavernous malformations: current status and future prospects.Semantic proximity Read ↗

Endothelial cell disease: emerging knowledge from cerebral cavernous malformationsSemantic proximity Read ↗

Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.