Article
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
Nature genetics - 1 Apr 2010
McGovern Dermot P B, Gardet Agnès, Törkvist Leif, Goyette Philippe, Essers Jonah, Taylor Kent D, Neale Benjamin M, Ong Rick T H, Lagacé Caroline, Li Chun, Green Todd, Stevens Christine R, Beauchamp Claudine, Fleshner Phillip R, Carlson Marie, D'Amato Mauro, Halfvarson Jonas, Hibberd Martin L, Lördal Mikael, Padyukov Leonid, Andriulli Angelo, Colombo Elisabetta, Latiano Anna, Palmieri Orazio, Bernard Edmond-Jean, Deslandres Colette, Hommes Daan W, de Jong Dirk J, Stokkers Pieter C, Weersma Rinse K, Sharma Yashoda, Silverberg Mark S, Cho Judy H, Wu Jing, Roeder Kathryn, Brant Steven R, Schumm L Phillip, Duerr Richard H, Dubinsky Marla C, Glazer Nicole L, Haritunians Talin, Ippoliti Andy, Melmed Gil Y, Siscovick David S, Vasiliauskas Eric A, Targan Stephan R, Annese Vito, Wijmenga Cisca, Pettersson Sven, Rotter Jerome I, Xavier Ramnik J, Daly Mark J, Rioux John D, Seielstad Mark
Abstract excerpt
Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract with a complex genetic and environmental etiology. In an effort to identify genetic variation underlying ulcerative colitis risk, we present two distinct genome-wide association studies of ulcerative colitis and their joint analysis with a previously published scan, comprising, in aggregate, 2,693 individuals with...
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