Article
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.
PLoS genetics - 20 Apr 2007
Libioulle Cécile, Louis Edouard, Hansoul Sarah, Sandor Cynthia, Farnir Frédéric, Franchimont Denis, Vermeire Séverine, Dewit Olivier, de Vos Martine, Dixon Anna, Demarche Bruno, Gut Ivo, Heath Simon, Foglio Mario, Liang Liming, Laukens Debby, Mni Myriam, Zelenika Diana, Van Gossum André, Rutgeerts Paul, Belaiche Jacques, Lathrop Mark, Georges Michel
Abstract excerpt
To identify novel susceptibility loci for Crohn disease (CD), we undertook a genome-wide association study with more than 300,000 SNPs characterized in 547 patients and 928 controls. We found three chromosome regions that provided evidence of disease association with p-values between 10(-6) and 10(-9). Two of these (IL23R on Chromosome 1 and CARD15 on Chromosome 16) correspond to genes previously reported to be...
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