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Article

Rare and common variant discovery in complex disease: the IBD case study

25 Jul 2019

Abstract excerpt

Complex diseases such as inflammatory bowel disease (IBD), which consists of ulcerative colitis and Crohn's disease, are a significant medical burden-70 000 new cases of IBD are diagnosed in the United States annually. In this review, we examine the history of genetic variant discovery in complex disease with a focus on IBD. We cover methods that have been applied to microsatellite, common variant, targeted...

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PMID: 31363759
DOI: 10.1093/hmg/ddz189

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