Article
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.
Nature genetics - 1 Jun 2008
Franke Andre, Balschun Tobias, Karlsen Tom H, Hedderich Jürgen, May Sandra, Lu Tim, Schuldt Dörthe, Nikolaus Susanna, Rosenstiel Philip, Krawczak Michael, Schreiber Stefan
Abstract excerpt
Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2,...
Topics
- Adult
- Biomarkers
- Case-Control Studies
- Chromosomes, Human, Pair 3
- Cohort Studies
- Colitis, Ulcerative
- Crohn Disease
- Female
- Genetic Predisposition to Disease
- Genetic Variation