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Article

Transcription factors PU.1 and IRF4 regulate activation induced cytidine deaminase in chicken B cells.

Molecular immunology - 1 Apr 2010

Luo Hong, Tian Ming

Abstract excerpt

The chicken immunoglobulin (Ig) variable region is preceded by multiple pseudo genes. During B cell maturation, the Ig variable region is converted into various pseudo gene sequences, and the diversity of antigen binding site is expanded as a consequence. Ig gene conversion is initiated by a B ce...

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Identifiers

PMID: 20299102
DOI: 10.1016/j.molimm.2010.02.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20299102-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Transcription factors PU.1 and IRF4 regulate activation induced cytidine deaminase in chicken B cells.PMID 20299102Read ↗

Negative regulation of Activation-Induced Cytidine Deaminase gene transcription in developing B cells by a PU.1-interacting intronic regionSemantic proximity Read ↗

Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion.Semantic proximity Read ↗

Immunoglobulin gene conversion or hypermutation: that's the question.Semantic proximity Read ↗

Separation of mutational and transcriptional enhancers in Ig genes.Semantic proximity Read ↗

AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene.Semantic proximity Read ↗

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Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.Semantic proximity Read ↗

Immunoglobulin gene conversion: insights from bursal B cells and the DT40 cell line.Semantic proximity Read ↗

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.Semantic proximity Read ↗

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1.Semantic proximity Read ↗

Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID‐mediated deoxycytidine deaminationSemantic proximity Read ↗

E2A Expression Stimulates Ig HypermutationSemantic proximity Read ↗

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