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Article

AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene.

Molecular immunology - 1 Apr 2008

Gopal Anjali R, Fugmann Sebastian D

Abstract excerpt

Somatic hypermutation (SHM) and gene conversion (GCV) are closely related processes that increase the diversity the primary immunoglobulin repertoire. In both processes the activation-induced cytidine deaminase (AID) converts cytosine residues to uracils within the DNA of the immunoglobulin (Ig) genes in a transcription-dependent manner, and subsequent error-prone repair processes lead to changes in the antigen...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18023479
DOI: 10.1016/j.molimm.2007.10.017
PMCID: PMC2267867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene.PMID 18023479Read ↗

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