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Article

E2A Expression Stimulates Ig Hypermutation

1 Jul 2006

Abstract excerpt

Ig hypermutation is limited to a region of approximately 2 kb downstream of the transcription start sites of the Ig loci. The process requires transcription and the presence of Ig enhancer sequences, and is initiated by the activation-induced cytidine deaminase (AID)-mediated deamination of cytidine bases. It remains unknown why AID causes mutations selectively in the Ig genes and not in most other transcribed...

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PMID: 16785535
DOI: 10.4049/jimmunol.177.1.395

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