Article

Negative regulation of Activation-Induced Cytidine Deaminase gene transcription in developing B cells by a PU.1-interacting intronic region

2024-06-02

Abstract excerpt

Activation-induced cytidine deaminase (AID, encoded by Aicda ) plays a key role in somatic hypermutation and class switch recombination in germinal center B cells. However, off-target effects of AID are implicated in human leukemia and lymphoma. A mouse model of precursor B cell acute lymphoblastic leukemia driven by deletion of the related transcription factors PU.1 and Spi-B revealed C->T transition mutations c...

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Literature Corpus work: ca96e0fc-3835-57a8-b320-b7f0a867e355
DOI: 10.1101/2024.05.29.596448

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