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Article

Separation of mutational and transcriptional enhancers in Ig genes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2011

Kothapalli Naga Rama, Collura Kaitlin M, Norton Darrell D, Fugmann Sebastian D

Abstract excerpt

Secondary Ig gene diversification relies on activation-induced cytidine deaminase (AID) to create U:G mismatches that are subsequently fixed by mutagenic repair pathways. AID activity is focused to Ig loci by cis-regulatory DNA sequences named targeting elements. In this study, we show that in contrast to prevailing thought in the field, the targeting elements in the chicken IGL locus are distinct from classical...

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Source

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Identifiers

PMID: 21844395
DOI: 10.4049/jimmunol.1101568
PMCID: PMC3169751

Genes

IGL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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