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Article

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1.

Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2004

Ito Satomi, Nagaoka Hitoshi, Shinkura Reiko, Begum Nasim, Muramatsu Masamichi, Nakata Mikiyo, Honjo Tasuku

Abstract excerpt

Activation-induced cytidine deaminase (AID) is a molecule central to initiating class switch recombination, somatic hypermutation, and gene conversion of Ig genes. However, its mechanism to initiate these genetic alterations is still unclear. AID can convert cytosine to uracil on either mRNA or DNA and is involved in DNA cleavage. Although these events are expected to take place in the nucleus, overexpressed AID...

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Identifiers

PMID: 14769937
DOI: 10.1073/pnas.0307335101
PMCID: PMC357037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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