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Article

RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase.

Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2013

Liang Guoxin, Kitamura Kouichi, Wang Zhe, Liu Guangyan, Chowdhury Sajeda, Fu Weixin, Koura Miki, Wakae Kousho, Honjo Tasuku, Muramatsu Masamichi

Abstract excerpt

Activation-induced cytidine deaminase (AID) is essential for the somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes. The mechanism by which AID triggers SHM and CSR has been explained by two distinct models. In the DNA deamination model, AID converts cytidine bases in DNA into uridine. The uridine is recognized by the DNA repair system, which produces DNA strand breakages and point...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23341589
DOI: 10.1073/pnas.1221921110
PMCID: PMC3568302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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