Article
Cloned human TCR from patients with autoimmune disease can respond to two structurally distinct autoantigens.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2004
De Silva-Udawatta Mihiri, Kumar Senthil R, Greidinger Eric L, Hoffman Robert W
Abstract excerpt
There is increasing evidence that the TCR can have significant plasticity in the range of Ags that a single receptor can recognize. Although it has been proposed that such TCR plasticity might contribute to autoimmunity, there have been few studies examining this possibility in either animal models or human disease. In the present study, we examined human T cell clones that were generated against two structurally...
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