Article
Sequence analysis of immunoglobulin heavy-chain variable region genes from the synovium of a rheumatoid arthritis patient shows little evidence of mutation but diverse CDR3.
Immunology - 1 Mar 1995
Brown C M, Fitzgerald K J, Moyes S P, Mageed R A, Williams D G, Maini R N
Abstract excerpt
To gain insight into the nature of B-lymphocyte responses in the synovium of rheumatoid arthritis (RA) patients, we amplified and sequenced immunoglobulin heavy-chain variable region genes expressed in seven IgM and three IgG-secreting synovial-derived hybridomas established from one patient. Eac...
Topics
- Arthritis, Rheumatoid
- B-Lymphocytes
- Base Sequence
- Cross Reactions
- DNA
- Female
- Humans
- Hybridomas
- Immunoglobulin G
- Immunoglobulin Heavy Chains
- Immunoglobulin M
- Immunoglobulin Variable Region
- Middle Aged
- Molecular Sequence Data
- Mutation