Novel pharmacokinetic behavior of intravenous busulfan in children with thalassemia undergoing hematopoietic stem cell transplantation: a prospective evaluation of pharmacokinetic and pharmacodynamic profile with therapeutic drug monitoring.

doi:10.1182/blood-2010-01-265405

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Article

Novel pharmacokinetic behavior of intravenous busulfan in children with thalassemia undergoing hematopoietic stem cell transplantation: a prospective evaluation of pharmacokinetic and pharmacodynamic profile with therapeutic drug monitoring.

Blood - 3 Jun 2010

Gaziev Javid, Nguyen Laurent, Puozzo Christian, Mozzi Alessia Francesca, Casella Marialuisa, Perrone Donnorso Michela, Gravina Paolo, Sodani Pietro, Marziali Marco, Isgrò Antonella, Simone Maria Domenica, Andreani Marco, Formosa Amanda, Testi Manuela, Federici Giorgio, Bernardini Sergio, Lucarelli Guido

Abstract excerpt

We prospectively studied the pharmacokinetics (PK) and clinical outcomes of intravenous busulfan (Bu) in 71 children with preexisting liver damage who underwent hematopoietic stem cell transplantation for thalassemia. Intravenous Bu was administered every 6 hours as part of a conditioning regimen with PK-based dose adjustment to target a conservative area under the concentration-versus-time curve (AUC) range...

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PMID: 20237319
DOI: 10.1182/blood-2010-01-265405

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GSTA1

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