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Article

Influence of glutathione S-transferase A1 polymorphism on the pharmacokinetics of busulfan.

Clinica chimica acta; international journal of clinical chemistry - 1 Jun 2006

Kusama Makiko, Kubota Takahiro, Matsukura Yuji, Matsuno Kumi, Ogawa Seishi, Kanda Yoshihiro, Iga Tatsuji

Abstract excerpt

BACKGROUND: High-dose oral busulfan is used for myeloablative chemotherapy before hematopoietic stem-cell transplantation. Fatal adverse effects or relapse may occur with excess or insufficient busulfan exposure. Glutathione S-transferase (GST) A1, whose genetic polymorphism in its promoter region has been reported, is responsible for busulfan metabolism. We investigated the polymorphism of GSTA1 on busulfan...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16448639
DOI: 10.1016/j.cca.2005.12.011

Genes

GSTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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