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Article

Incorporation of GSTA1 genetic variations into a population pharmacokinetic model for IV busulfan in paediatric hematopoietic stem cell transplantation.

British journal of clinical pharmacology - 1 Jul 2018

Nava Tiago, Kassir Nastya, Rezgui Mohamed Aziz, Uppugunduri Chakradhara Rao Satyanarayana, Huezo-Diaz Curtis Patricia, Duval Michel, Théoret Yves, Daudt Liane E, Litalien Catherine, Ansari Marc, Krajinovic Maja, Bittencourt Henrique

Abstract excerpt

AIMS: The aim of this study is to develop a population pharmacokinetic (PopPK) model for intravenous busulfan in children that incorporates variants of GSTA1, gene coding for the main enzyme in busulfan metabolism. METHODS: Busulfan concentration-time data was collected from 112 children and adolescents (median 5.4 years old, range: 0.1-20) who received intravenous busulfan during the conditioning regimen prior...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29469189
DOI: 10.1111/bcp.13566
PMCID: PMC6005620

Genes

GSTA1

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