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Article

Pharmacokinetic and pharmacogenetic analysis of oral busulfan in stem cell transplantation: prediction of poor drug metabolism to prevent drug toxicity.

Current drug safety - 1 Jul 2012

Krivoy Norberto, Zuckerman Tsila, Elkin Hela, Froymovich Lia, Rowe Jacob M, Efrati Edna

Abstract excerpt

High dose busulfan (BU) has become a mainstay in conditioning regimens for hematopoietic stem cell transplantation (HSCT), despite its unpredictable response, narrow therapeutic index and severe toxicity. The present study provides an integration of pharmacokinetic and genetic data of 63 adults w...

Read the complete abstract on PubMed

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Share to Administration, Oral
Share to ABCB1 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hematopoietic Stem Cell Transplantation

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 22950985
DOI: 10.2174/157488612803251324

Genes

ABCB1
GSTM1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22950985-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Pharmacokinetic and pharmacogenetic analysis of oral busulfan in stem cell transplantation: prediction of poor drug metabolism to prevent drug toxicity.PMID 22950985Read ↗

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