Article
Influence of glutathione S-transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation.
Pediatric blood & cancer - 1 Dec 2010
Elhasid Ronit, Krivoy Norberto, Rowe Jacob M, Sprecher Eli, Adler Lior, Elkin Hela, Efrati Edna
Abstract excerpt
BACKGROUND: Busulfan (BU), often used in high dose for myeloablation before hematopoietic stem cell transplantation (HSCT), has been implicated in certain HSCT toxicities, including the occurrence of hepatic veno-occlusive disease (HVOD). In addition to weight and age, gene polymorphisms in specific members of the glutathione-transferase (GST) gene family (A1, P1, M1, and T1), involved in BU metabolism, may play...
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