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Impact of Glutathione S-Transferase Polymorphisms on Busulfan Pharmacokinetics and Outcomes of Hematopoietic Stem Cell Transplantation.

Therapeutic drug monitoring - 1 Aug 2022

Al-Riyami Intisar, Al-Khabori Murtadha, Al Balushi Khalid, Al-Zadjali Shoaib, Al-Rawahi Mohammed, Dennison David, Al-Hunaini Mohammed, Al-Rawas Abdulhakeem, Al-Moundhri Mansour

Abstract excerpt

BACKGROUND: Busulfan (Bu) is an alkylating drug used in many preparative regimens before hematopoietic stem cell transplantation (HSCT). It is conjugated in the liver mainly by glutathione S-transferase isoenzyme A1-1 ( GSTA1 ). Genetic polymorphisms in these isoenzymes may affect the pharmacokinetics of Bu and the clinical outcomes of HSCT. This study aimed to assess the impact of glutathione S-transferase ( GST...

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PMID: 34990437
DOI: 10.1097/FTD.0000000000000957

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