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Article

GSTA1 Genetic Variants and Conditioning Regimen: Missing Key Factors in Dosing Guidelines of Busulfan in Pediatric Hematopoietic Stem Cell Transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Nov 2017

Nava Tiago, Rezgui Mohamed A, Uppugunduri Chakradhara R S, Curtis Patricia Huezo-Diaz, Théoret Yves, Duval Michel, Daudt Liane E, Ansari Marc, Krajinovic Maja, Bittencourt Henrique

Abstract excerpt

Busulfan (Bu) is a key component of conditioning regimens used before hematopoietic stem cell transplantation (SCT) in children. Different predictive methods have been used to calculate the first dose of Bu. To evaluate the necessity of further improvements, we retrospectively analyzed the currently available weight- and age-based guidelines to calculate the first doses in 101 children who underwent allogenic SCT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28807770
DOI: 10.1016/j.bbmt.2017.07.022

Genes

GSTA1
SCT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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