Article
Population pharmacokinetic analysis of intravenous busulfan: GSTA1 genotype is not a predictive factor of initial dose in Chinese adult patients undergoing hematopoietic stem cell transplantation.
Cancer chemotherapy and pharmacology - 1 Feb 2020
Sun Yidan, Huang Jingjing, Hao Chenxia, Li Ziwei, Liang Wu, Zhang Weixia, Chen Bing, Yang Wanhua, Hu Jiong
Abstract excerpt
PURPOSE: This study aimed to develop a population pharmacokinetic (PPK) model to investigate the impact of GSTA1, GSTP1, and GSTM1 genotypes on busulfan pharmacokinetic (PK) variability in Chinese adult patients. METHODS: Forty-three and 19 adult patients who underwent hematopoietic stem cell transplantation (HSCT) were enrolled for modeling group and validation group, respectively. All patients received...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.