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Article

Glutathione S-transferase A1 genetic variants reduce busulfan clearance in children undergoing hematopoietic cell transplantation.

Journal of clinical pharmacology - 1 Sept 2008

Johnson L'Aurelle, Orchard Paul J, Baker K Scott, Brundage Richard, Cao Qing, Wang Xinjing, Langer Erica, Farag-El Maasah Sharein, Ross Julie A, Remmel Rory, Jacobson Pamala A

Abstract excerpt

The effect of glutathione S-transferase variants on pediatric busulfan metabolism was investigated by noncompartmental and population pharmacokinetic modeling. Twenty-nine children who underwent related or unrelated bone marrow or umbilical cord blood hematopoietic cell transplant were retrospectively studied. GSTA1, GSTP1, and GSTM1 variants were explored for their effects on busulfan exposures. Noncompartmental...

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Source

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Identifiers

PMID: 18635758
DOI: 10.1177/0091270008321940
PMCID: PMC3204946

Genes

GSTA1
GSTM1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glutathione S-transferase A1 genetic variants reduce busulfan clearance in children undergoing hematopoietic cell transplantation.PMID 18635758Read ↗

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