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Article

Glutathione S-transferase A1 genetic variants reduce busulfan clearance in children undergoing hematopoietic cell transplantation.

Journal of clinical pharmacology - 1 Sept 2008

Johnson L'Aurelle, Orchard Paul J, Baker K Scott, Brundage Richard, Cao Qing, Wang Xinjing, Langer Erica, Farag-El Maasah Sharein, Ross Julie A, Remmel Rory, Jacobson Pamala A

Abstract excerpt

The effect of glutathione S-transferase variants on pediatric busulfan metabolism was investigated by noncompartmental and population pharmacokinetic modeling. Twenty-nine children who underwent related or unrelated bone marrow or umbilical cord blood hematopoietic cell transplant were retrospect...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18635758
DOI: 10.1177/0091270008321940
PMCID: PMC3204946

Genes

GSTA1
GSTM1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18635758-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Glutathione S-transferase A1 genetic variants reduce busulfan clearance in children undergoing hematopoietic cell transplantation.PMID 18635758Read ↗

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