Article
Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.
Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2010
Zhao Tong-Jin, Liang Guosheng, Li Robert Lin, Xie Xuefen, Sleeman Mark W, Murphy Andrew J, Valenzuela David M, Yancopoulos George D, Goldstein Joseph L, Brown Michael S
Abstract excerpt
Ghrelin O-acyltransferase (GOAT) attaches octanoate to proghrelin, which is processed to ghrelin, an octanoylated peptide hormone that stimulates release of growth hormone (GH) from pituitary cells. Elimination of the gene encoding ghrelin or its receptor produces only mild phenotypes in mice. Thus, the essential function of ghrelin is obscure. Here, we eliminate the Goat gene in mice, thereby eliminating all...
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