Article
The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction.
PloS one - 1 Jan 2012
Yi Chun-Xia, Heppner Kristy M, Kirchner Henriette, Tong Jenny, Bielohuby Maximillian, Gaylinn Bruce D, Müller Timo D, Bartley Erin, Davis Harold W, Zhao Yongmei, Joseph Anupama, Kruthaupt Traci, Ottaway Nickki, Kabra Dhiraj, Habegger Kirk M, Benoit Stephen C, Bidlingmaier Martin, Thorner Michael O, Perez-Tilve Diego, Tschöp Matthias H, Pfluger Paul T
Abstract excerpt
OBJECTIVE: Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance. Using a unique set of four different genetic loss-of-function models for the GOAT/ghrelin/growth hormone secretagogue receptor (GHSR) system, we thoroughly tested the hypothesis that lack-of-ghrelin activation or signaling would...
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