Article
Genetic and functional analysis of human P2X5 reveals a distinct pattern of exon 10 polymorphism with predominant expression of the nonfunctional receptor isoform.
Molecular pharmacology - 1 Jun 2010
Kotnis Smita, Bingham Brendan, Vasilyev Dmitry V, Miller Scott W, Bai Yuchen, Yeola Sarita, Chanda Pranab K, Bowlby Mark R, Kaftan Edward J, Samad Tarek A, Whiteside Garth T
Abstract excerpt
P2X5 is a member of the P2X family of ATP-gated nonselective cation channels, which exist as trimeric assemblies. P2X5 is believed to trimerize with another member of this family, P2X1. We investigated the single-nucleotide polymorphism (SNP) at the 3' splice site of exon 10 of the human P2X5 gene. As reported previously, presence of a T at the SNP location results in inclusion of exon 10 in the mature...
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