Article
Activation of trimeric P2X2 receptors by fewer than three ATP molecules.
Molecular pharmacology - 1 Oct 2012
Stelmashenko Olga, Lalo Ulyana, Yang Yue, Bragg Laricia, North R Alan, Compan Vincent
Abstract excerpt
P2X receptors are trimeric membrane proteins. When they bind extracellular ATP, a conformational change occurs that opens a transmembrane ion channel. The ATP-binding pocket is formed in a cleft between two subunits, and a critical amino acid residue for ATP contact is Lys⁶⁹ (P2X2 numbering). In the present work, we sought to determine whether the binding of fewer than three ATP molecules could open the ion...
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