P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity.

doi:10.1111/bph.15830

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Article

P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity.

British journal of pharmacology - 1 Jul 2022

Gasparri Federica, Sarkar Debayan, Bielickaite Sarune, Poulsen Mette Homann, Hauser Alexander Sebastian, Pless Stephan Alexander

Abstract excerpt

BACKGROUND AND PURPOSE: P2X receptors are trimeric ligand-gated ion channels that open a cation-selective pore in response to ATP binding to their large extracellular domain. The seven known P2X subtypes can assemble as homotrimeric or heterotrimeric complexes and contribute to numerous physiological functions, including nociception, inflammation and hearing. The overall structure of P2X receptors is well...

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PMID: 35285517
DOI: 10.1111/bph.15830
PMCID: PMC9314836

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