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Article

Accumulation of intraneuronal Abeta correlates with ApoE4 genotype.

Acta neuropathologica - 1 May 2010

Christensen Ditte Z, Schneider-Axmann Thomas, Lucassen Paul J, Bayer Thomas A, Wirths Oliver

Abstract excerpt

In contrast to extracellular plaque and intracellular tangle pathology, the presence and relevance of intraneuronal Abeta in Alzheimer's disease (AD) is still a matter of debate. Human brain tissue offers technical challenges such as post-mortem delay and uneven or prolonged tissue fixation that might affect immunohistochemical staining. In addition, previous studies on intracellular Abeta accumulation in human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20217101
DOI: 10.1007/s00401-010-0666-1
PMCID: PMC2849938

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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