Article
The load and distribution of beta-amyloid in brain tissue of patients with Alzheimer's disease.
Acta neurologica Scandinavica - 1 Feb 2001
Kraszpulski M, Soininen H, Helisalmi S, Alafuzoff I
Abstract excerpt
Recent findings have underlined the significance of beta-amyloid protein (betaA4) in the etiology of Alzheimer's disease (AD). In 60 patients with AD, the amount of betaA4 deposition, estimated applying immunohistochemical techniques, was shown to be significantly influenced by apolipoprotein E (ApoE) genotype (epsilon4/epsilon4 > epsilon4/x > x/x), by the age at onset (presenile > senile), by the age at death...
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