Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetics of Congenital Heart Defects: The NKX2-5 Gene, a Key Player

23 Jan 2016

Abstract excerpt

Congenital heart defects (CHDs) represent the biggest fraction of morbid congenital anomalies worldwide. Owing to their complex inheritance patterns and multifactorial etiologies, these defects are difficult to identify before complete manifestation. Research over the past two decades has established firmly the role of genetics in the development of these congenital defects. While syndromic CHDs are more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Congenital Heart Disease Studies
Share to Tracheal and airway disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26805889
DOI: 10.3390/genes7020006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetics of Congenital Heart Defects: The NKX2-5 Gene, a Key PlayerPMID 26805889Read ↗

NKX2-5: an update on this hypermutable homeodomain protein and its role in human congenital heart disease (CHD)Semantic proximity Read ↗

Novel NKX2-5 mutations responsible for congenital heart disease.Semantic proximity Read ↗

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways.Semantic proximity Read ↗

Congenital heart disease caused by mutations in the transcription factor NKX2-5.Semantic proximity Read ↗

Functional analysis of novel genetic variants of NKX2-5 associated with nonsyndromic congenital heart disease.Semantic proximity Read ↗

Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling.Semantic proximity Read ↗

Investigation of NKX2.5 gene mutations in congenital heart defects in an Indian population.Semantic proximity Read ↗

Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit.Semantic proximity Read ↗

Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders.Semantic proximity Read ↗

NKX2.5 mutations in patients with non-syndromic congenital heart diseaseSemantic proximity Read ↗

Cardiac homeobox gene NKX2-5mutations and congenital heart diseaseSemantic proximity Read ↗

The molecular genetics of congenital heart disease: a review of recent developments.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.