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Article

Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2008

Vincentz Joshua W, Barnes Ralston M, Firulli Beth A, Conway Simon J, Firulli Anthony B

Abstract excerpt

The interactions of diverse transcription factors mediate the molecular programs that regulate mammalian heart development. Among these, Nkx2.5 and the Mef2c regulate common downstream targets and exhibit striking phenotypic similarities when disrupted, suggesting a potential interaction during h...

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Share to Cell Differentiation
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeobox Protein Nkx-2.5

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Share to Myocardium

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Source

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Identifiers

PMID: 19035347
DOI: 10.1002/dvdy.21803
PMCID: PMC2639719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19035347-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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