Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantitative trait loci modifying cardiac atrial septal morphology and risk of patent foramen ovale in the mouse.

Circulation research - 17 Mar 2006

Kirk Edwin P, Hyun Changbaig, Thomson Peter C, Lai Donna, Castro M Leticia, Biben Christine, Buckley Michael F, Martin Ian C A, Moran Chris, Harvey Richard P

Abstract excerpt

Atrial septal defect (ASD) is a common congenital heart disease (CHD) occurring in 5 to 7 per 10,000 live births. Mutations in 5 human genes (NKX2.5, TBX5, GATA4, MYHC, ACTC) are known to cause dominant ASD, but these account for a minority of cases. Human and mouse data suggest that ASD exists in an anatomical continuum with milder septal variants patent foramen ovale (PFO) and atrial septal aneurysm, strongly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Linkage
Share to Heart Atria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Septal Defects, Atrial

Share to Lod Score

Share to Phenotype

Share to Quantitative Trait Loci

Share to Risk Factors

Source

Identifiers

PMID: 16484617
DOI: 10.1161/01.RES.0000209965.59312.aa

Genes

GATA4
TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantitative trait loci modifying cardiac atrial septal morphology and risk of patent foramen ovale in the mouse.PMID 16484617Read ↗

Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross lineSemantic proximity Read ↗

Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line.Semantic proximity Read ↗

Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5.Semantic proximity Read ↗

Complex trait analysis of ventricular septal defects caused by Nkx2-5 mutation.Semantic proximity Read ↗

Heterogeneity of genetic modifiers ensures normal cardiac development.Semantic proximity Read ↗

Molecular Pathways and Animal Models of Atrial Septal Defect.Semantic proximity Read ↗

Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities.Semantic proximity Read ↗

Genetic Mouse Models of Autism Spectrum Disorder Present Subtle Heterogenous Cardiac AbnormalitiesSemantic proximity Read ↗

<i>Pitx2</i> prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specificationSemantic proximity Read ↗

Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septationSemantic proximity Read ↗

Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16.Semantic proximity Read ↗

The fitness cost of a congenital heart defect shapes its genetic architectureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.