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Article

A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels.

Differentiation; research in biological diversity - 1 Jan 2000

Furtado Milena B, Wilmanns Julia C, Chandran Anjana, Tonta Mary, Biben Christine, Eichenlaub Michael, Coleman Harold A, Berger Silke, Bouveret Romaric, Singh Reena, Harvey Richard P, Ramialison Mirana, Pearson James T, Parkington Helena C, Rosenthal Nadia A, Costa Mauro W

Abstract excerpt

Nkx2-5 is one of the master regulators of cardiac development, homeostasis and disease. This transcription factor has been previously associated with a suite of cardiac congenital malformations and impairment of electrical activity. When disease causative mutations in transcription factors are considered, NKX2-5 gene dysfunction is the most common abnormality found in patients. Here we describe a novel mouse...

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Share to Disease Models, Animal
Share to ERG1 Potassium Channel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Heart Defects, Congenital

Share to Homeobox Protein Nkx-2.5

Share to Ion Channels

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Identifiers

PMID: 26897459
DOI: 10.1016/j.diff.2015.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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