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Article

Cardiac conduction and arrhythmia: insights from Nkx2.5 mutations in mouse and humans.

Novartis Foundation symposium - 1 Jan 2003

Jay Patrick Y, Berul Charles I, Tanaka Makoto, Ishii Masao, Kurachi Yoshihisa, Izumo Seigo

Abstract excerpt

The phenotypes of cardiac conduction and rhythm disorders are very well characterized because of the large numbers of affected patients who seek medical treatment. The few disorders where the genetic basis is known has led to a commonly held notion that the abnormal function of ion pumps, channels and connexins (ICC) causes conduction defects and arrhythmias. Although probably true in general, the ICC-centric...

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PMID: 12956333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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