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Article

Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders.

Cold Spring Harbor perspectives in medicine - 1 Oct 2014

Prendiville Terence, Jay Patrick Y, Pu William T

Abstract excerpt

Study of monogenic congenital heart disease (CHD) has provided entry points to gain new understanding of heart development and the molecular pathogenesis of CHD. In this review, we discuss monogenic CHD caused by mutations of the cardiac transcription factor genes NKX2-5 and GATA4. Detailed investigation of these genes in mice and humans has expanded our understanding of heart development, shedding light on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25274754
DOI: 10.1101/cshperspect.a013946
PMCID: PMC4200204

Genes

GATA4

Provenance

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