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Article

Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death

27 Aug 2020

Abstract excerpt

Abstract Expression of the transcription factor brachyury (TBXT) is normally restricted to the embryo, and its silencing is epigenetically regulated. TBXT promotes mesenchymal transition in a subset of common carcinomas, and in chordoma, a rare cancer showing notochordal differentiation, TBXT acts as a putative oncogene. We hypothesized that TBXT expression is controlled through epigenetic inhibition to promote...

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PMID: 32855205
DOI: 10.1158/0008-5472.can-20-1387

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Related research

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Research trail→

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Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell DeathPMID 32855205Read ↗

Epigenetic inactivation of oncogenic brachyury (TBXT) by H3K27 histone demethylase controls chordoma cell survivalSemantic proximity Read ↗

Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordomaSemantic proximity Read ↗

Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordomaSemantic proximity Read ↗

Transcriptional Profiling Supports the Notochordal Origin of Chordoma and Its Dependence on a TGFB1-TBXT NetworkSemantic proximity Read ↗

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An integrated functional genomics approach identifies the regulatory network directed by brachyury (<i>T</i>) in chordomaSemantic proximity Read ↗

All-trans retinoic acid (ATRA) reduces proliferative capacity and Brachyury levels in chordoma cellsSemantic proximity Read ↗

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The Roles of Embryonic Transcription Factor BRACHYURY in Tumorigenesis and ProgressionSemantic proximity Read ↗

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