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Article

Impaired peroxisome proliferator-activated receptor-gamma contributes to phenotypic modulation of vascular smooth muscle cells during hypertension.

The Journal of biological chemistry - 30 Apr 2010

Zhang Lili, Xie Peng, Wang Jingzhou, Yang Qingwu, Fang Chuanqin, Zhou Shuang, Li Jingcheng

Abstract excerpt

The phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a pivotal role in hypertension-induced vascular changes including vascular remodeling. The precise mechanisms underlying VSMC phenotypic modulation remain elusive. Here we test the role of peroxisome proliferator-activated receptor (PPAR)-gamma in the VSMC phenotypic modulation during hypertension. Both spontaneously hypertensive rat (SHR)...

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Identifiers

PMID: 20212046
DOI: 10.1074/jbc.M109.087718
PMCID: PMC2859529

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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