Article
Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension.
Cell metabolism - 1 Mar 2008
Halabi Carmen M, Beyer Andreas M, de Lange Willem J, Keen Henry L, Baumbach Gary L, Faraci Frank M, Sigmund Curt D
Abstract excerpt
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-activated transcription factor that plays a critical role in metabolism. Thiazolidinediones, high-affinity PPARgamma ligands used clinically to treat type II diabetes, have been reported to lower blood pressure and provide other cardiovascular benefits. Some mutations in PPARgamma (PPARG) cause type II diabetes and severe hypertension. Here...
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