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Article

PPARβ/δ, a Novel Regulator for Vascular Smooth Muscle Cells Phenotypic Modulation and Vascular Remodeling after Subarachnoid Hemorrhage in Rats.

Scientific reports - 22 Mar 2017

Zhang Hongrong, Jiang Li, Guo Zongduo, Zhong Jianjun, Wu Jingchuan, He Junchi, Liu Han, He Zhaohui, Wu Haitao, Cheng Chongjie, Sun Xiaochuan

Abstract excerpt

Cerebral vascular smooth muscle cell (VSMC) phenotypic switch is involved in the pathophysiology of vascular injury after aneurysmal subarachnoid hemorrhage (aSAH), whereas the molecular mechanism underlying it remains largely speculative. Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) has been implicated to modulate the vascular cells proliferation and vascular homeostasis. In the present study, we...

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PMID: 28327554
DOI: 10.1038/srep45234
PMCID: PMC5361085

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