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Article

SREBF1 maintains the contractile phenotype of vascular smooth muscle cells via PPARγ signalling.

Prostaglandins & other lipid mediators - 1 Jan 2026

Chen Xiaoying, Jin Huiling, Zheng Guanyi

Abstract excerpt

BACKGROUND: Atherosclerosis is a complex chronic inflammatory disease. Although SREBF1 has been implicated in the regulation of atherosclerotic progression, its precise mechanisms remain incompletely understood. METHODS: The study constructed an in vitro model of atherosclerosis by exposing vascular smooth muscle cells (VSMCs) to oxidized low-density lipoprotein. The model was validated through inverted...

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Share to Atherosclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipoproteins, LDL

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Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

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Source

Identifiers

PMID: 41412334
DOI: 10.1016/j.prostaglandins.2025.107054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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