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Article

Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2009

Meredith Dane, Panchatcharam Manikandan, Miriyala Sumitra, Tsai Yau-Sheng, Morris Andrew J, Maeda Nobuyo, Stouffer George A, Smyth Susan S

Abstract excerpt

OBJECTIVE: The peroxisome proliferator activated receptor-gamma (PPARgamma) protein is a nuclear transcriptional activator with importance in diabetes management as the molecular target for the thiazolidinedione (TZD) family of drugs. Substantial evidence indicates that the TZD family of PPARgamma agonists may retard the development of atherosclerosis. However, recent clinical data have suggested that at least...

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Identifiers

PMID: 19179641
DOI: 10.1161/ATVBAHA.109.184234
PMCID: PMC2773202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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