Article
Base pairing constraints drive structural epistasis in ribosomal RNA sequences.
Molecular biology and evolution - 1 Aug 2010
Dutheil Julien Y, Jossinet Fabrice, Westhof Eric
Abstract excerpt
It has long been accepted that the structural constraints stemming from the 3D structure of ribosomal RNA (rRNA) lead to coevolution through compensating mutations between interacting sites. State-of-the-art methods for detecting coevolving sites, however, while reaching high levels of specificity and sensitivity for Watson-Crick (WC) pairs of the helices defining the secondary structure, only scarcely reveal...
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