Article

Extracting the phylogenetic dimension of coevolution reveals hidden functional signal

2020-09-25

Abstract excerpt

Despite the structural and functional information contained in the statistical coupling between pairs of residues in a protein, coevolution associated with function is often obscured by artifactual signals such as genetic drift, which shapes a protein’s phylogenetic history and gives rise to concurrent variation between protein sequences that is not driven by selection for function. Here, we introduce a method for...

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Literature Corpus work: e284f10d-8a72-5ee1-9804-36fd937cb92f
DOI: 10.1101/2020.09.23.310300

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