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Article

Coevolution in RNA molecules driven by selective constraints: evidence from 5S rRNA.

PloS one - 1 Jan 2012

Cheng Nan, Mao Yuanhui, Shi Youyi, Tao Shiheng

Abstract excerpt

Understanding intra-molecular coevolution helps to elucidate various structural and functional constraints acting on molecules and might have practical applications in predicting molecular structure and interactions. In this study, we used 5S rRNA as a template to investigate how selective constraints have shaped the RNA evolution. We have observed the nonrandom occurrence of paired differences along the...

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Identifiers

PMID: 22973441
DOI: 10.1371/journal.pone.0044376
PMCID: PMC3433437

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